Table 2 from Comparison of Bone Metastases between 18F-NaF PET/CT, 18F-NaF PET, and Planar 99mTc-MDP Bone Scintigraphy in Patients with Newly Diagnosed Nasopharyngeal Carcinoma | Semantic Scholar (2025)

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The biodistribution data show TTHMP has a high uptake in the bone and is excreted rapidly through urinary system, and it is suggested that [^99mTc]Tc-TTHMP can be a candidate for skeletal system imaging.

In patients with nasopharyngeal carcinoma, 18F-NaF PET/CT assessed invasion of the skull base better and detected more osseous metastases than18F-FDGPET/CT and the two examinations were compared using per-patient- based analysis and per-lesion-based analysis.

The sensitivities of 18F-fluoride PET/CT and 99mTc bone scintigraphy (SPECT) were significantly higher than those of18F-FDG PET/ CT and 99MTcBone scintography (planar) (p < 0.05).

PBS, as a conventional imaging, should be used as an important complement for detecting bone metastasis in NPC patients, and PET/CT was found to be more sensitive on lesion level than PBS.

The authors' pilot phase prospective trial demonstrated superior image quality and evaluation of skeletal disease extent with 18F NaF PET/CT compared to 99mTc-MDP scintigraphy and 18F FDGPET/CT, as well as the feasibility of multisequence WBMRI.

18F-NaF PET-CT is a highly sensitive and specific modality for the detection of BM in patients with preoperative lung cancer and is better than conventional 99m-technetium methylene diphosphonate single photon emission computed tomography (SPECT) in detecting BM.

F-FDG PET/CT has a higher diagnostic value than 99mTc-MDP whole-body BS in the detection of osteolytic bone metastases, especially in the vertebra.

NaF PET/CT and SPECT/CT showed numerically improved, but not statistically superior, sensitivity compared with BS in this limited and selected patient cohort.

In the present cohort of patients with breast cancer, 18F-NaF PET/CT detected bone metastases in 42% with an accuracy of 0.93, and the scan results led to a change in patient management in 25%.

The interobserver agreement and the diagnostic performance in 18F-NaF PET/computed tomography for the detection of skull-base bone invasion and osseous metastases in patients with newly diagnosed nasopharyngeal carcinoma were both very high among trained observers, rendering NaFPET/CT a robust tool in the diagnostic armamentarium.

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